ABSTRACT BACKGROUND: Work-related musculoskeletal disorders (WMSDs) currently pose a challenge to public health and elicit considerable financial, physical and social problems for workers. There is a need to attain a deeper understanding of this predicament among office workers, in order to tackle it successfully. This study sought to investigate the prevalence of WMSDs among office workers in Higher Education Institutions (HEIs) as well as discover its associations with their personal/work details and reported risk factors.METHODS: A cross-sectional survey was executed among 217 office workers in different HEIs, who filled self-report questionnaires on WMSDs. Data were analyzed via descriptive and inferential statistics.RESULTS: The overall prevalence rate of WMSDs was 71.9% among these staff. The lower back, wrists/hands and shoulders were the most reported body regions for these disorders. WMSD prevalence had significant associations with sex (p = 0.004), age (p = 0.028), working hours (p = 0.003) and work experience (p = 0.014). There were significant positive relationships (p < 0.05) between WMSD prevalence and these risk factors: awkward posture, sustained body position, improper bending, workplace stress, inappropriate furniture and inadequate rest breaks.CONCLUSION: Most of the study participants were affected with WMSDs, which were primarily reported in the back and upper extremities. Office workers who were older, female, more experienced and work for longer hours, displayed higher risks for these disorders and should be given special attention. Several factors reported by these HEI staff were revealed to significantly influence WMSD prevalence, emphasizing the need for their effective detection and curtailment.KEYWORDS: Work-related Musculoskeletal Disorder, WMSD, Office workers, Higher education institution, HEI