IntroductionEvidence-based medicine miracle has embraced all the sciences (1-5). This movement improved medical practice using the critical thinking (1, 6-9). In the meantime, systematic reviews are one of the best available evidence by apprising preliminary studies. Systematic reviews and meta-analyses have become increasingly important in health care. In addition, these studies are increasing globally in different healthcare settings (10-13). It is estimated that around 22 new systematic reviews are published every day. The evidence suggest that almost 50 systematic reviews are published every day (14). The purpose of this study was to introduce the type, necessities, and applications of reviews of systematic reviews for evidence-based medicine.With the increase in the number of systematic reviews, a fundamental next step to provide decision-makers in healthcare with the evidence they require has been the conduct of reviews of existing systematic reviews and evidence brief. The reviews of systematic reviews are referred to by several different terms in the scientific evidence, including umbrella reviews, overviews of reviews, meta-review, review of reviews, a summary of systematic reviews and also a synthesis of reviews (15). The reviews of systematic reviews are a relatively new method of evidence synthesis. Each reviews of systematic reviews focuses on a broad condition or problem for which there are two or more potential interventions and highlights reviews that address these potential interventions and their results (15, 16).