TO THE EDITOR: Adaptation to environmental change is principle of living things evolution and mutation is one of the main driving force of this natural process. Viruses are no exception and exploit different mechanisms for induction of mutations and genetic variation to ensure their survival. The rates of mutations varies among different types of viruses. For instance, RNA viruses have higher mutation rates than DNA viruses because of the error nature of viral RNA-dependent RNA polymerases(RdRp). The rate of new mutations may also be higher in some of the RNA viruses due to mutations in viral polymerase that can decrease polymerase fidelity. Although, high mutation rates are necessary for virus virulence and evolvability but almost they can compromise existing adaptations and can lead to viral extinction (1, 2). These observations have raised questions about the beneficial or deleterious effects of SARS-CoV-2 mutations.