BACKGROUND: Healthcare is a knowledge driven process and thus knowledge management and the tools to manage knowledge in healthcare sector are gaining attention. The aim of this systematic review is to investigate knowledge management implementation and knowledge management tools used in healthcare for informed decision making.METHODS: Three databases, two journals websites and Google Scholar were used as sources for the review. The key terms used to search relevant articles include:  “Healthcare and Knowledge Management”; “Knowledge Management Tools in Healthcare” and “Community of Practices in healthcare”.RESULTS: It was found that utilization of knowledge management in healthcare is encouraging. There exist numbers of opportunities for knowledge management implementation, though there are some barriers as well. Some of the opportunities that can transform healthcare are advances in health information and communication technology, clinical decision support systems, electronic health record systems, communities of practice and advanced care planning. CONCLUSION: Providing the right knowledge at the right time, i.e., at the point of decision making by implementing knowledge management in healthcare is paramount. To do so, it is very important to use appropriate tools for knowledge management and user-friendly system because it can significantly improve the quality and safety of care provided for patients both at hospital and home settings. KEYWORDS: Knowledge management, tools, evidence-based medical practice, healthcare, informed decision making