BACKGROUND: In Ethiopia, objective evidences showing pathologic features and clinical characteristics predicting the extent of coronary artery disease are scanty. The present study is aimed at assessing factors associated with the extent of coronary artery disease and the attained outcomes in patients undergoing percutaneous coronary intervention.METHODS: A retrospective observational study of 197 patients that have undergone percutaneous coronary intervention was undertaken. Data were entered using Epi data version 4.2 and exported to Statistical Package for Social Science version 25 for analysis. Descriptive statistics such as frequencies and percentages were used to summarize the findings. Logistic regression was carried out to test the association between dependent and independent variables. RESULTS: The mean age of the study participants was 58.6 with standard deviation (SD) of 11.5 and male to female ratio of 4.2. The majority, [110 (55.8%)], had ST segment elevation myocardial infarction. Nearly two-third of the study participants had documented heart failure. Dyslipidemia [AOR 4.2(95%; CI:1.29-14.00)] and left ventricular hypertrophy [AOR 4.1(95%; CI:1.38-12.40)] were associated with extent of coronary artery disease on adjusted analysis. In the large majority, 169 patients (85.8%), thrombolysis in myocardial infarction 3 flow grade was achieved.Conclusion: Dyslipidemia and left ventricular hypertrophy predicted multi-vessel coronary artery disease. There is a high frequency of post myocardial infarction heart failure, underscoring the need for centers of excellence and implementation of health education programs targeting the importance of primary prevention and timely revascularization. The success rate of percutasneous coronary intervention at Gesund Cardiac and Medical Center is praiseworthy.KEYWORDS: coronary artery disease, percutaneous coronary intervention, Ethiopia